|
KMID : 0861020110260030001
|
|
Korea Journal of Herbology
2011 Volume.26 No. 3 p.1 ~ p.6
|
|
|
Effect of Citri Pericarpium ethanol extract on collagen-induced arthritis in mice
|
|
Jung Jin-Ki
Son Kun-Ho
Kim Yeong-Shik
Park Yong-Ki
|
|
|
Abstract
|
|
|
Objectives:The present study was undertaken to determine whether an ethanol extract of Citri Pericarpium (CP-E), which is the pericarp of Citrus unshiu Markovich is efficacious against collagen-induced arthritis (CIA) in mice.
Methods: CIA was induced in male DBA/1J mice by intradermal injection of bovine collagen-II in Freund’s incomplete adjuvant (IFA). The mice in the onset of arthritis were treated daily with oral administration of CP-E ethanol extract at different doses (50 and 100 mg/kg/bw) for 28 days. Arthritis index, histopathologic changes and the levels of TNF-α as well as anti-CII IgG in blood were evaluated to confirm the anti-arthritic effect of CP-E on CIA in rats.
Results:The results showed that comparing with untreated CIA mice, treated with CP-E extract significantly decreased the arthritic scores and the pathological changes of knee joint tissues, and also reduced the serum levels of TNF-α and anti-CII IgG in CIA-mice. These results indicate that CP-E extract may effectively alleviate inflammatory response on CIA, and its anti-inflammation can be attributed, at least partially, to the inhibition of proinflamamtory cytokine, TNF-α in CIA.
Conclusions: This study suggest that CP-E has a therapeutic potential in inflammatory joint diseases such as rheumatoid arthritis.
|
|
|
KEYWORD
|
|
|
Citri Pericarpium, anti-arthritis, collagen-induced arthriis, inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|